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NF157

CAT: 0804-HY-108672Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108672Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 μM, 170 μM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 μM), P2Y2 (Ki=28.9 μM), respectively[1]. NF157, significantly reduces expression of metalloproteinase (MMP) -3, MMP-13, can be used in the treatment of osteoarthritis (OA) [2].
CAS Number
104869-26-3
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nf157.html
Purity
92.90
Solubility
H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2F)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6F)=O)=CC=C5
Molecular Formula
C49H28F2N6Na6O23S6
Molecular Weight
1437.10
References & Citations
[1]Ullmann H, et al. Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem. 2005 Nov 3;48 (22) :7040-8.|[2]Wang D, et al. Inhibition of P2Y11R ameliorated TNF-α-induced degradation of extracellular matrix in human chondrocytic SW1353 cells. Am J Transl Res. 2019 Apr 15;11 (4) :2108-2116.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y11 Receptor

Alternative Products

CatalogName
T16291NF157

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