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HLI373

CAT: 0804-HY-108640Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108640Size:1 Each
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Description
HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents[1]. Antimalarial activity[2].
CAS Number
502137-98-6
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/hli373.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C2N(C)C3=C(C=CC=C3)C(NCCCN(C)C)=C2C(N1C)=O
Molecular Formula
C18H23N5O2
Molecular Weight
341.41
References & Citations
[1]Jirouta Kitagaki, et al. Targeting Tumor Cells Expressing p53 With a Water-Soluble Inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7 (8) :2445-54.|[2]Jagrati Jain, et al. Inhibitors of Ubiquitin E3 Ligase as Potential New Antimalarial Drug Leads. BMC Pharmacol Toxicol. 2017 Jun 2;18 (1) :40.|[3]Ying Chen, et al. MDM2 Promotes Epithelial-Mesenchymal Transition and Metastasis of Ovarian Cancer SKOV3 Cells. Br J Cancer. 2017 Oct 10;117 (8) :1192-1201.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

Alternative Products

CatalogName
551003HLI373
T36733-01HLI373 dihydrochloride
217415Hdm2 E3 Ligase Inhibitor II, HLI373 (5- (3-Dimethylaminopropylamino) -3,10-dimethyl-10H-pyrimido[4,5-b]quinoline-2,4-dione, 2HCl, MDM2 Inhibitor VI, MDM2 E3 Ligase Inhibitor II)

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