RuBi-4AP

• UNSPSC Description:

  RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation[1][2].

• Target Antigen:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/rubi-4ap.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=CC=[N]([Ru+2]23([N]4=CC=CC=C4C5=CC=CC=[N]35)([N]6=CC=C(N)C=C6)[N]7=CC=CC=C7C8=CC=CC=[N]28)C=C1.[Cl-].[Cl-]

• Molecular Weight:

  672.57

• References & Citations:

  [1]Zayat L, et al. A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage. J Am Chem Soc. 2003 Jan 29;125(4):882-3.|[2]Rowan MJ, et al. Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. J Neurosci. 2014 May 7;34(19):6611-23.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  851956-02-0