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A-784168

CAT: 0804-HY-108460-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108460-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1) . Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration[1].
CAS Number
824982-41-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-784168.html
Concentration
10mM
Purity
99.7900
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CCN(C2=NC=CC=C2C(F)(F)F)CC1)NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3
Molecular Formula
C19H15F6N3O3S
Molecular Weight
479.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Cui M, et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J Neurosci. 2006;26 (37) :9385-9393.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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4319/10A 784168
A22264-25A 784168 25mg
A22264-5A 784168 5mg
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A22264-50A 784168 50mg

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