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AMG8379

CAT: 0804-HY-108425Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108425Size:1 Each
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Description
AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX) -sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM[1].
CAS Number
1642112-31-9
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amg8379.html
Solubility
10 mM in DMSO
Smiles
O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=C(OC)C=C(C(F)=C4)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O
Molecular Formula
C25H16ClF2N3O5S
Molecular Weight
543.93
References & Citations
[1]Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362 (1) :146-160.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7

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