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BLI-489 (hydrate)

CAT: 0804-HY-108062ASize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108062ASize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BLI-489 hydrate, a penem β-lactamase inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens[1][2].
CAS Number
2580120-08-5
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bli-489-hydrate.html
Purity
99.0
Solubility
H2O : 20 mg/mL (ultrasonic; warming) |DMSO : 24 mg/mL (ultrasonic)
Smiles
O=C(C1=CS[C@@](/C2=C/C3=CN4C(COCC4)=N3)([H])N1C2=O)O[Na].[x].O
Molecular Formula
C13H12N3NaO5S.xH2O
References & Citations
[1]Petersen PJ, et al. Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. Antimicrob Agents Chemother. 2009;53 (2) :370-384.|[2]Petersen PJ, et al. Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection. Antimicrob Agents Chemother. 2009;53 (4) :1698-1700.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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