BLI-489 (hydrate)

• Description:

  BLI-489 hydrate, a penem β-lactamase inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens[1][2].

• UNSPSC:

  12352005

• Target:

  Bacterial; Beta-lactamase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/bli-489-hydrate.html

• Purity:

  99.0

• Solubility:

  H2O : 20 mg/mL (ultrasonic; warming) |DMSO : 24 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CS[C@@] (/C2=C/C3=CN4C (COCC4) =N3) ([H]) N1C2=O) O[Na].[x].O

• Molecular Formula:

  C13H12N3NaO5S.xH2O

• References & Citations:

  [1]Petersen PJ, et al. Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. Antimicrob Agents Chemother. 2009;53 (2) :370-384.|[2]Petersen PJ, et al. Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection. Antimicrob Agents Chemother. 2009;53 (4) :1698-1700.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2580120-08-5