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4-Hydroxyoxyphenbutazone

CAT: 0804-HY-108050Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108050Size:1 Each
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Description
4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard agents. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive agent and has the potential for rheumatoid arthritis research[1][2].
CAS Number
55648-39-0
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-hydroxyoxyphenbutazone.html
Solubility
10 mM in DMSO
Smiles
O=C1N(N(C(C1(CCCC)O)=O)C2=CC=C(C=C2)O)C3=CC=CC=C3
Molecular Formula
C19H20N2O4
Molecular Weight
340.37
References & Citations
[1]Ben Gold, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. |[2]Anja Ten Brinke, et al. 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production. Eur Cytokine Netw. 2005 Jun;16 (2) :144-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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