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Antibiotic DC 81

CAT: 0804-HY-107767Size: 1 EachDry Ice: NoHazardous: No
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Description
Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine) . Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct[1][2].
CAS Number
81307-24-6
Product Name Alternative
DC 81
UNSPSC
12352005
Target
Antibiotic; Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antibiotic-dc-81.html
Solubility
H2O
Smiles
O=C1C2=CC(OC)=C(O)C=C2N=C[C@@]3([H])N1CCC3
Molecular Formula
C13H14N2O3
Molecular Weight
246.26
References & Citations
[1]Hu WP, et al. Biological evaluation of an antibiotic DC-81-indole conjugate agent in human melanoma cell lines. Kaohsiung J Med Sci. 2003 Jan;19 (1) :6-12. |[2]Lee CH, et al. Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo. Chem Biol Interact. 2009 Aug 14;180 (3) :360-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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