CGS35066

CAT: 0804-HY-107762Size: 10 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-107762Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1) . CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively[1].

CAS Number

261619-50-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endothelin-Converting Enzyme (ECE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cgs35066.html

Solubility

10 mM in DMSO

Smiles

O=P(O)(O)CN[C@H](C(O)=O)CC1=CC=C(C2=CC=CC=C2O3)C3=C1

Molecular Formula

C16H16NO6P

Molecular Weight

349.28

Precautions

H302, H315, H319, H335

References & Citations

[1]A J Trapani, et al. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J Cardiovasc Pharmacol. 2000 Nov;36 (5 Suppl 1) :S40-3.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature 3 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CGS35066

Popular Products