Macbecin

• Description :

  Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].

• Product Name Alternative :

  Macbecin I; NSC 330499

• UNSPSC :

  12352005

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/macbecin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C(NC(/C(C)=C/C=C/[C@H](C)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H](OC)[C@@H](OC)C[C@@H]1C)=O)=C2)C([C@]1([H])OC)=CC2=O

• Molecular Formula :

  C30H42N2O8

• Molecular Weight :

  558.66

• References & Citations :

  [1]Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51 (9) :2853-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP90

• CAS Number :

  [73341-72-7]