Macbecin

• Description:

  Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].

• Product Name Alternative:

  Macbecin I; NSC 330499

• UNSPSC:

  12352005

• Target:

  HSP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/macbecin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(NC(/C(C)=C/C=C/[C@H](C)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H](OC)[C@@H](OC)C[C@@H]1C)=O)=C2)C([C@]1([H])OC)=CC2=O

• Molecular Formula:

  C30H42N2O8

• Molecular Weight:

  558.66

• References & Citations:

  [1]Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51 (9) :2853-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HSP90

• CAS Number:

  [73341-72-7]