(±) -HIP-A

• Description :

  (±) -HIP-A is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC50=17-18 μM) . (±) -HIP-A is also a lead compound against ischemia-induced neuronal degeneration. (±) -HIP-A can be used in the study of neurological diseases[1].

• UNSPSC :

  12352005

• Target :

  EAAT

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/racemic-hip-a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC([C@@H]1[C@]2([H])[C@](ONC2=O)([H])CN1)=O

• Molecular Formula :

  C6H8N2O4

• Molecular Weight :

  172.14

• References & Citations :

  [1]Andrea Pinto, et al. Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [227619-64-9]