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Thiomarinol A

CAT: 0804-HY-107164Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107164Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1].
CAS Number
146697-04-3
Product Name Alternative
4-Hydroxythiomarinol C
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thiomarinol-a.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]([C@@]1([H])[C@@H]([C@@H]([C@H](CO1)C/C=C/[C@@H](C)[C@@H](O)C)O)O)/C(C)=C/C(OCCCCCCCC(NC2=C3C(NC2=O)=CSS3)=O)=O
Molecular Formula
C30H44N2O9S2
Molecular Weight
640.81
References & Citations
[1]Johnson RA, et al. Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. J Am Chem Soc. 2021 Aug 11;143 (31) :12003-12013.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19221725-01Thiomarinol A

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