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Unoprostone

CAT: 0804-HY-106916Size: 1 mg (26.14 mM x 100 μL in Methyl Acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-106916Size:1 mg (26.14 mM x 100 μL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Unoprostone, a prostaglandin F2α analog, is a large conductance Ca2+-activated K+ (BK) channels and ClC-2 type chloride channels activator. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and can be used for the study of glaucoma, ocular hypertension and retinitis pigmentosa[1][2].
CAS Number
120373-36-6
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
Chloride Channel; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/unoprostone.html
Concentration
26.14 mM * 100 μL in Methyl acetate
Purity
99.0
Solubility
10 mM in DMSO
Smiles
OC(CCC/C=C\C[C@@H]1[C@H]([C@H](O)C[C@@H]1O)CCC(CCCCCCC)=O)=O
Molecular Formula
C22H38O5
Molecular Weight
382.53
Precautions
H302, H312, H332
References & Citations
[1]Tsuruma K, et al. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytoticdysfunction, by activating BK channels. Mol Vis. 2011;17:3556-65. Epub 2011 Dec 30.|[2]Kelly CR, et al. Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and otheranalogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors. J Pharmacol Exp Ther. 2003 Jan;304 (1) :238-45.|[3]Ota T, et al. The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. Invest Ophthalmol Vis Sci. 2005 Nov;46 (11) :4159-63.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
Launched

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