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Israpafant

CAT: 0804-HY-106837Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106837Size:1 Each
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Description
Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca2+ influx and intracellular Ca2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice[1][2].
CAS Number
117279-73-9
Product Name Alternative
Y 24180
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/israpafant.html
Solubility
10 mM in DMSO
Smiles
CC1=NN=C2N1C3=C(C(C4=C(Cl)C=CC=C4)=NC2C)C=C(S3)CCC5=CC=C(C=C5)CC(C)C
Molecular Formula
C28H29ClN4S
Molecular Weight
489.07
References & Citations
[1]Takehara S, et al. Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF) : II. Interactions with PAF and benzodiazepine receptors. Prostaglandins. 1990 Dec;40 (6) :571-83.|[2]Jan C R, Chao Y Y. Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca2+ levels and growth of human prostate cancer cells. Cellular signalling, 2004, 16 (8) : 959-965.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
T27638-01Israpafant

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