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Arimoclomol

CAT: 0804-HY-106443-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106443-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP) [1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].Arimoclomol can be used for the study of Niemann–Pick disease type C.
CAS Number
289893-25-0
Product Name Alternative
BRX-220 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arimoclomol.html
Purity
99.83
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2
Molecular Formula
C14H20ClN3O3
Molecular Weight
313.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32 (12) :1283-92.|[2]Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13 (7) :482-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HSP
Citation 01
Res Sq. 2025 Mar 31.|University of Tubingen. 2025.|Exp Eye Res. 2019 Nov;188:107792.|Iran J Med Sci. 2024 May 16.|University of Graz. Institute of Pharmaceutical Science. 2021 Nov.

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