Arimoclomol

• Description :

  Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP) [1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].Arimoclomol can be used for the study of Niemann–Pick disease type C.

• Product Name Alternative :

  BRX-220 (free base)

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/arimoclomol.html

• Purity :

  99.83

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2

• Molecular Formula :

  C14H20ClN3O3

• Molecular Weight :

  313.78

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32 (12) :1283-92.|[2]Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13 (7) :482-96.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  HSP

• Citation 01 :

  Res Sq. 2025 Mar 31.|University of Tubingen. 2025.|Exp Eye Res. 2019 Nov;188:107792.|Iran J Med Sci. 2024 May 16.|University of Graz. Institute of Pharmaceutical Science. 2021 Nov.

• CAS Number :

  [289893-25-0]