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Delmitide

CAT: 0804-HY-106359Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106359Size:1 Each
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Description
Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL) -12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis[1][2].
CAS Number
287096-87-1
Product Name Alternative
RDP-58
UNSPSC
12352209
Target
IFNAR; Reactive Oxygen Species (ROS) ; TNF Receptor
Type
Peptides
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/delmitide.html
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@@H](N)C(N[C@H](CCCC)C(N[C@H](CCCC)C(N[C@H](CCCC)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCC)C(N[C@H](CCCC)C(N[C@H](CCCC)C(NCC(N[C@@H](C(N)=O)CC1=CC=C(C=C1)O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C59H105N17O11
Molecular Weight
1228.57
References & Citations
[1]Arthur Kaser, et al. Novel therapeutic targets in the treatment of IBD. Kaser, Arthur; Tilg, Herbert (2008) . Expert Opinion on Therapeutic Targets, 12 (5), 553–563. |[2]Jingsong Zhao, et al. Oral RDP58 allows CPT-11 dose intensification for enhanced tumor response by decreasing gastrointestinal toxicity. Clin Cancer Res. 2004 Apr 15;10 (8) :2851-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2

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