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LB80317

CAT: 0804-HY-106235Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106235Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment[1][2].
CAS Number
441785-24-6
UNSPSC
12352005
Target
DNA/RNA Synthesis; HBV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lb80317.html
Solubility
10 mM in DMSO
Smiles
OP(O)(COC1(CN2C=NC3=C2N=C(N)NC3=O)CC1)=O
Molecular Formula
C10H14N5O5P
Molecular Weight
315.22
References & Citations
[1]Man-Fung Yuen, et al. Pharmacokinetics of LB80331 and LB80317 Following Oral Administration of LB80380, a New Antiviral Agent for Chronic Hepatitis B (CHB), in Healthy Adult Subjects, CHB Patients, and Mice. Antimicrob Agents Chemother. 2009 May;53 (5) :1779-85.|[2]Lung-Yi Mak, et al. Pharmacokinetic Evaluation of Besifovir for the Treatment of HBV Infection. Expert Opin Drug Metab Toxicol. 2018 Jan;14 (1) :101-106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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