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Tiprelestat

CAT: 0804-HY-106216Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106216Size:1 Each
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Description
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease[1].
CAS Number
820211-82-3
UNSPSC
12352209
Target
Elastase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tiprelestat.html
Solubility
10 mM in DMSO
Smiles
[Tiprelestat]
Molecular Formula
C254H416N72O75S10
Molecular Weight
5999.09
References & Citations
[1]Wang J, et al. Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice. Sci Rep. 2020 Jul 30;10 (1) :12785. |[2]Alejandre Alcazar MA, et al. Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice. Am J Respir Cell Mol Biol. 2018 Nov;59 (5) :623-634. |[3]Bellemare A, et al. Human pre-elafin inhibits a Pseudomonas aeruginosa-secreted peptidase and prevents its proliferation in complex media. Antimicrob Agents Chemother. 2008 Feb;52 (2) :483-90. |[4]Butler MW, et al. Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. J Biol Chem. 2006 Nov 17;281 (46) :34730-5.|[5]Nickel NP, et al. Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling. Am J Respir Crit Care Med. 2015 Jun 1;191 (11) :1273-86.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2

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