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Nocloprost

CAT: 0804-HY-106054Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-106054Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nocloprost, a prostaglandin E2 (PGE2) analog, is an orally active EP1- and EP3-receptor agonist. Nocloprost inhibits evoked [3H]ACh release. Nocloprost has gastroprotective and ulcer-healing properties. Nocloprost accelerates the healing of chronic gastric ulcerations and enhances mucosal growth in rats[1][2].
CAS Number
79360-43-3
UNSPSC
12352211
Hazard Statement
H225, H319, H336, H360
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nocloprost.html
Solubility
10 mM in DMSO
Smiles
CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H]([C@H](Cl)C[C@H]1O)C/C=C\CCCC(O)=O
Molecular Formula
C22H37ClO4
Molecular Weight
400.98
Precautions
H225, H319, H336, H360
References & Citations
[1]S J Konturek, et al. Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. Eur J Pharmacol. 1991 Apr 3;195 (3) :347-57.|[2]T Reinheimer, et al. Prostanoid receptors of the EP3 subtype mediate inhibition of evoked [3H]acetylcholine release from isolated human bronchi. Br J Pharmacol. 1998 Sep;125 (2) :271-6.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP

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