Products for Research Use Only
RegisterLogin

Rilpivirine-d6

CAT: 0804-HY-10574SSize: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10574SSize:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Rilpivirine-d6 is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI) . Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM) . Rilpivirine has a high genetic barrier to resistance development of HIV[1][2].
CAS Number
1312424-26-2
UNSPSC
12352005
Target
HIV; Isotope-Labeled Compounds; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C(C=C(C=C1C([2H])([2H])[2H])/C=C/C#N)=C1NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2
Molecular Formula
C22H12D6N6
Molecular Weight
372.46
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Janssen PAJ, et, al. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[ (1E) -2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine) . J Med Chem. 2005 Mar 24;48 (6) :1901-9.|[3]Azijn H, et, al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. Antimicrob Agents Chemother. 2010 Feb;54 (2) :718-27.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10574-01Rilpivirine
HY-167642(Z) -Rilpivirine
HY-10574S1Rilpivirine-13C6
HY-10574R-01Rilpivirine (Standard)
HY-10574A-01Rilpivirine (hydrochloride)
HY-157075S(Z) -Rilpivirine-d4
HY-10574AR-01Rilpivirine (hydrochloride) (Standard)
HY-110225-01Levetiracetam-d6 (ring-d6)
HY-N0893STetrahydrocurcumin-d6
HY-W750155Tetramethrin-d6

Alternative Products

CatalogName
MCC42426-01Rilpivirine-d6
AR-R01600-01Rilpivirine-d6 HCl
CS-O-63181N-Nitroso Rilpivirine 1-d6
T2330-01Rilpivirine

Popular Products