Nomegestrol

• Description:

  Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

• UNSPSC:

  12352211

• Hazard Statement:

  H315-H319-H320

• Target:

  Progesterone Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Nomegestrol.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@]([C@]4([H])C(C(C)=C3)=CC(CC4)=O)([H])CC1

• Molecular Formula:

  C21H28O3

• Molecular Weight:

  328.45

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56 (6) :325-8.|[2]Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76 (6) :531-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [58691-88-6]