Nomegestrol

• Description :

  Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

• UNSPSC :

  12352211

• Hazard Statement :

  H315-H319-H320

• Target :

  Progesterone Receptor

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Nomegestrol.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@]([C@]4([H])C(C(C)=C3)=CC(CC4)=O)([H])CC1

• Molecular Formula :

  C21H28O3

• Molecular Weight :

  328.45

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56 (6) :325-8.|[2]Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76 (6) :531-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [58691-88-6]