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Heliquinomycin

CAT: 0804-HY-105387Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105387Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].
CAS Number
178182-49-5
UNSPSC
12352005
Hazard Statement
H302+H312, H319
Target
Bacterial; DNA/RNA Synthesis; Topoisomerase
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/heliquinomycin.html
Solubility
10 mM in DMSO
Smiles
OC1=C([C@H]([C@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C3C[C@H]2O)O5)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)OC)C5=C(O)C(C(C(OC)=C7)=O)=C1C7=O
Molecular Formula
C33H30O17
Molecular Weight
698.58
Precautions
H302+H312, H319
References & Citations
[1]Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) . 1996 Aug;49 (8) :752-7. |[2]Chino M, et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo) . 1998 May;51 (5) :480-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I; Topo II

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