VU0285683

CAT: 0804-HY-103571-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103571-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM) . VU0285683 has anxiolytic-like activity in rodent models for anxiety[1].
CAS Number
[327056-22-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0285683.html
Purity
99.76
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC(C2=NC(C3=NC=CC=C3)=NO2)=CC(F)=C1
Molecular Formula
C14H7FN4O
Molecular Weight
266.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78 (6) :1105-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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