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A-841720

CAT: 0804-HY-103550Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103550Size:1 mg
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Description
A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research[1][2].
CAS Number
869802-58-4
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-841720.html
Purity
98.0
Solubility
DMSO : 15 mg/mL (ultrasonic; warming)
Smiles
O=C1C2=C(C3=C(N(C)C)C=CN=C3S2)N=CN1N4CCCCCC4
Molecular Formula
C17H21N5OS
Molecular Weight
343.45
References & Citations
[1]O El-Kouhen, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006 Nov;149 (6) :761-74.|[2]Lorenzo Morè, et al. Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18 (4) :273-81.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1; mGluR5

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