A-841720

• Description :

  A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research[1][2].

• CAS Number :

  [869802-58-4]

• UNSPSC :

  12352005

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/a-841720.html

• Purity :

  98.0

• Solubility :

  DMSO : 15 mg/mL (ultrasonic; warming)

• Smiles :

  O=C1C2=C(C3=C(N(C)C)C=CN=C3S2)N=CN1N4CCCCCC4

• Molecular Formula :

  C17H21N5OS

• Molecular Weight :

  343.45

• References & Citations :

  [1]O El-Kouhen, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006 Nov;149 (6) :761-74.|[2]Lorenzo Morè, et al. Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18 (4) :273-81.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR1; mGluR5