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Nemonapride

CAT: 0804-HY-103415-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103415-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals[1][2][3].
CAS Number
75272-39-8
Product Name Alternative
YM-09151-2; Emonapride
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nemonapride.html
Purity
99.90
Solubility
DMF : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(N[C@H]1[C@@H](C)N(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(NC)C=C3OC
Molecular Formula
C21H26ClN3O2
Molecular Weight
387.90
Precautions
H302
References & Citations
[1]Terai M, et al. Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn J Pharmacol. 1983 Aug;33 (4) :749-55. |[2]Seeman P, Van Tol HH. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15 (7) :264-70.|[3]Assié MB, et al. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur J Pharmacol. 1997 Sep 10;334 (2-3) :141-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; D2 Receptor; mLAG-3

Alternative Products

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B6843-10Nemonapride
018063Trans-Nemonapride
sc-208454Trans Nemonapride
N1010-50Nemonapride (rel-5-Chloro-2-methoxy-4- (methylamino) -N-[ (2R,3R) -2-methyl-2- (phennylmethyl) -3-pyrrolidinyl]benzamide)
MBS6115043-01Nemonapride (rel-5-Chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-2-(phennylmethyl)-3-pyrrolidinyl]benzamide)

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