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NSC693868

CAT: 0804-HY-103381Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103381Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].
CAS Number
40254-90-8
UNSPSC
12352005
Target
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc693868.html
Purity
99.0
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
NC1=NNC2=NC3=CC=CC=C3N=C21
Molecular Formula
C9H7N5
Molecular Weight
185.19
References & Citations
[1]Ortega MA, et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg Med Chem. 2002 Jul;10 (7) :2177-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK5; GSK-3β

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