NAADP

• UNSPSC Description:

  NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/naadp.html

• Purity:

  95.8

• Solubility:

  H2O : 50 mg/mL (ultrasonic;warming)

• Smiles:

  O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H]([N+]5=CC=CC(C(O)=O)=C5)[C@@H]([C@@H]4O)O)([O-])=O)(O)=O

• Molecular Weight:

  744.39

• References & Citations:

  [1]Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. |[2]Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22(24):2331-7. |[3]Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  5502-96-5