NAADP

• Description :

  NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/naadp.html

• Purity :

  95.8

• Solubility :

  H2O : 50 mg/mL (ultrasonic; warming)

• Smiles :

  NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OC[C@H]4O[C@@H]([N+]5=CC(C(O)=O)=CC=C5)[C@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3OP(O)([O-])=O

• Molecular Formula :

  C21H27N6O18P3

• Molecular Weight :

  744.39

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. |[2]Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22 (24) :2331-7. |[3]Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31 (7) :3126-3137.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [5502-96-5]