LUF5834

• Description :

  LUF5834 is a selective A2B adenosine receptor (A2BR) partial agonist (EC50 = 12 nM) . LUF5834 is also a partial A1/A2A adenosine receptor agonist (lacking selectivity) with Ki values of 2.6 and 28 nM, respectively[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Adenosine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/luf5834.html

• Purity :

  99.8

• Solubility :

  DMSO : 20 mg/mL (ultrasonic; warming)

• Smiles :

  N#CC1=C(C2=CC=C(O)C=C2)C(C#N)=C(SCC3=NC=CN3)N=C1N

• Molecular Formula :

  C17H12N6OS

• Molecular Weight :

  348.38

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Beukers MW, et al. New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. J Med Chem. 2004 Jul 15;47 (15) :3707-9. |[2]Lane JR, et al. A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A (2a) receptor. Mol Pharmacol. 2012 Mar;81 (3) :475-87.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR)

• CAS Number :

  [333962-91-7]