LY393558

CAT: 0804-HY-103089Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103089Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression[1].

CAS Number

271780-64-4

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly393558.html

Purity

99.0

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=CC=C(N(CCN2CC=C(C3=CNC4=C3C=CC(F)=C4)CC2)S(N(C(C)C)C5)(=O)=O)C5=C1)(C)=O

Molecular Formula

C26H31FN4O4S2

Molecular Weight

546.68

References & Citations

[1]Mitchell SN, et al. LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT (1B/1D) receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat. Eur J Pharmacol. 2001;432 (1) :19-27.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor

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