Cavidine

• Description :

  Cavidine ((+) -Cavidine) is a selective COX-2 inhibitor which possesses anti-inflammatory activity. Cavidine can be used for the research of skin injuries, hepatitis, cholecystitis, and scabies. Cavidine ameliorates LPS (HY-D1056) -induced acute lung injury via NF-κB signaling pathway[1][2][3].

• Product Name Alternative :

  (+) -Cavidine

• UNSPSC :

  12352005

• Target :

  COX

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cavidine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@H]1C(C=C2)=C(C3=C2OCO3)CN4CCC5=CC(OC)=C(OC)C=C5[C@@]14[H]

• Molecular Formula :

  C21H23NO4

• Molecular Weight :

  353.41

• References & Citations :

  [1]Niu X, et, al. Anti-inflammatory effects of cavidine in vitro and in vivo, a selective COX-2 inhibitor in LPS-induced peritoneal macrophages of mouse. Inflammation. 2015 Apr;38 (2) :923-33.|[2]Niu X, et, al. Protective effect of cavidine on acetic acid-induced murine colitis via regulating antioxidant, cytokine profile and NF-κB signal transduction pathways. Chem Biol Interact. 2015 Sep 5:239:34-45.|[3]Niu X, et, al. Cavidine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via NF-κB Signaling Pathway in vivo and in vitro. Inflammation. 2017 Aug;40 (4) :1111-1122.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [32728-75-9]