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Sematilide

CAT: 0804-HY-101436Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101436Size:1 Each
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Description
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM) . Sematilide is a class III antiarrhythmic agent[1].
CAS Number
101526-83-4
Product Name Alternative
CK-1752
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sematilide.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1
Molecular Formula
C14H23N3O3S
Molecular Weight
313.42
References & Citations
[1]Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331 (2-3) :295-302.|[2]Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS579690Sematilide (CK-1752)

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