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Chlorisondamine (diiodide)

CAT: 0804-HY-101347Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101347Size:5 mg
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Description
Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way[1].
CAS Number
96750-66-2
UNSPSC
12352005
Hazard Statement
H302, H410
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chlorisondamine-diiodide.html
Purity
99.6
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
C[N+](CC[N+]1(C)CC2=C(C(Cl)=C(Cl)C(Cl)=C2Cl)C1)(C)C.[I-].[I-]
Molecular Formula
C14H20Cl4I2N2
Molecular Weight
611.94
Precautions
H302, H410
References & Citations
[1]Clarke PB, et al. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994 Feb;111 (2) :397-405. |[2]Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83 (2) :527-535. doi:10.1111/j.1476-5381.1984.tb16517.x|[3]Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83 (2) :527-535. doi:10.1111/j.1476-5381.1984.tb16517.x
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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