MRS2179 (tetrasodium)

MRS2179 (tetrasodium)

• CAS Number: 1454889-37-2
• UNSPSC Description: MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors[1][2]. MRS2179 tetrasodium inhibits platelet aggregation[3].
• Target Antigen: P2Y Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/mrs2179-tetrasodium.html
• Solubility: 10 mM in DMSO
• Smiles: CNC1=C2C(N([C@](C[C@@H]3O[P](O[Na])(O[Na])=O)([H])O[C@@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1
• Molecular Weight: 513.16
• References & Citations: [1]Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842.|[2]von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006;110(3):415-432.|[3]Baurand A, Raboisson P, Freund M, et al. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur J Pharmacol. 2001;412(3):213-221.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported