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2-MPMDQ

CAT: 0804-HY-101061Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101061Size:1 Each
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Description
2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM) . 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research[1].
CAS Number
149847-77-8
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2-mpmdq.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C)C2=C(C=CC=C2)C3=NC(CN4CCN(C5=CC=CC=C5OC)CC4)CN13
Molecular Formula
C23H27N5O2
Molecular Weight
405.49
References & Citations
[1]J W Chern, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem. 1993 Jul 23;36 (15) :2196-207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor

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