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Metaphit

CAT: 0804-HY-100998Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100998Size:1 Each
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Description
Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].
CAS Number
96316-00-6
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/metaphit.html
Solubility
10 mM in DMSO
Smiles
S=C=NC1=CC(C2(N3CCCCC3)CCCCC2)=CC=C1
Molecular Formula
C18H24N2S
Molecular Weight
300.46
References & Citations
[1]E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140 (3) :267-74|[2]M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181 (2) :318-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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M3009-45BMetaphit Methanesulfonate Salt (1- (1-[3-Isothiocyanato]phenyl) cyclohexylpiperidine, Methanesulfonate Salt)
MBS6089256-01Metaphit Methanesulfonate Salt (1-(1-[3-Isothiocyanato]phenyl)cyclohexylpiperidine, Methanesulfonate Salt)

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