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L-NIO

CAT: 0804-HY-100986BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100986BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO induces a consistentfocal ischemic infarctin rats[2].
CAS Number
36889-13-1
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/l-nio.html
Solubility
10 mM in DMSO
Smiles
CC(NCCC[C@@H](C(O)=O)N)=N
Molecular Formula
C7H15N3O2
Molecular Weight
173.21
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Babu BR, et al. N5- (1-Imino-3-butenyl) -L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273 (15) :8882-9.|[2]Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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