2-Hydroxysaclofen

• Description :

  2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats[1][2][3].

• CAS Number :

  [117354-64-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H314

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/2-hydroxysaclofen.html

• Purity :

  98.0

• Solubility :

  H2O : 50 mg/mL (ultrasonic; adjust pH to 11 with 1 M NaOH)

• Smiles :

  O=S(CC(O)(CN)C1=CC=C(Cl)C=C1)(O)=O

• Molecular Formula :

  C9H12ClNO4S

• Molecular Weight :

  265.71

• Precautions :

  H314

• References & Citations :

  [1]Varani AP, et al. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5.|[2]Miranda F, et al. The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure. Pharmacol Biochem Behav. 2009 Jul;93 (1) :25-30.|[3]Akema T, et al. 2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. Brain Res. 1991 Apr 12;546 (1) :143-5.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported