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2-Hydroxysaclofen

CAT: 0804-HY-100812Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100812Size:1 mg
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Description
2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats[1][2][3].
CAS Number
117354-64-0
UNSPSC
12352005
Hazard Statement
H314
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-hydroxysaclofen.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic; adjust pH to 11 with 1 M NaOH)
Smiles
O=S(CC(O)(CN)C1=CC=C(Cl)C=C1)(O)=O
Molecular Formula
C9H12ClNO4S
Molecular Weight
265.71
Precautions
H314
References & Citations
[1]Varani AP, et al. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5.|[2]Miranda F, et al. The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure. Pharmacol Biochem Behav. 2009 Jul;93 (1) :25-30.|[3]Akema T, et al. 2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. Brain Res. 1991 Apr 12;546 (1) :143-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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