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Gp100 Antibody / PMEL17

CAT: 0013-GTR18083267-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18083267-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This mAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.This Mab labels formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
UniProt
P40967
Reactivity
Human
Immunogen
Membranes from a human melanoma metastasis were used as the immunogen for this anti-gp100 antibody.
Clonality
Monoclonal
Clone
SPM286
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The optimal dilution of the anti-gp100 antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · P40967

Melanocyte protein PMEL

PMEL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P40967
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PMEL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B3KS57, B7Z6D7, Q12763, Q14448, Q14817, Q16565
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Cellular component

Endoplasmic reticulumEndosomeGolgi apparatusMembraneSecreted

Biological process

Melanin biosynthesis

Domain

RepeatSignalTransmembraneTransmembrane helix

Ligand

Sialic acid

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