Cis-ACBD

• Description :

  Cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].

• Product Name Alternative :

  Cis-1-Aminocyclobutane-1,3-dicarboxylic acid

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cis-acbd.html

• Purity :

  98.0

• Solubility :

  H2O : 62.5 mg/mL (ultrasonic)

• Smiles :

  OC([C@]1(C[C@@H](C1)C(O)=O)N)=O

• Molecular Formula :

  C6H9NO4

• Molecular Weight :

  159.14

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71 (4) :192-8.|[2]Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47 (2) :267-74.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [73550-55-7]