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CH5138303

CAT: 0804-HY-100555-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100555-01Size:1 mg
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Description
CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90α, with Kd of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines (HCT116 and NCI-N87), with IC50 values of 0.098 and 0.066 μM, respectively. CH5138303 shows high oral bioavailability in mice (F=44.0%) . CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model[1][2].
CAS Number
959763-06-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ch5138303.html
Purity
99.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)CCCSC1=NC(N)=NC(C2=C(Cl)C=C3C4=C2C=CC=C4COC3)=N1
Molecular Formula
C19H18ClN5O2S
Molecular Weight
415.90
Precautions
H302, H315, H319, H335
References & Citations
[1]Atsushi Suda, et al. Design and synthesis of 2-amino-6- (1H,3H-benzo[de]isochromen-6-yl) -1,3,5-triazines as novel Hsp90 inhibitors. Bioorganic & Medicinal Chemistry. 15 January 2014;22 (2) :892-905.|[2]Yuan R, et al. Effects of Hsp90 Inhibitor Ganetespib on Inhibition of Azole-Resistant Candida albicans. Front Microbiol. 2021 May 20;12:680382.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

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