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Recombinant Cyclin D1 Antibody

CAT: 0013-GTR18083123-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18083123-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
UniProt
P24385
Reactivity
Human
Immunogen
A portion of amino acids 270-295 fro the human protein was used as the immunogen for the recombinant Cyclin D1 antibody.
Clonality
Recombinant
Clone
CCND1/3370R
Conjugation
Unconjugated
Field of Research
Cancer, DNA Damage, Epigenetics
Purification
Protein A affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Western blot: 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant Cyclin D1 antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Rabbit
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Rabbit IgG

UniProtKB · P24385

G1/S-specific cyclin-D1

CCND1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24385
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCND1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6LEF0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Cell cycleCell divisionDNA damageTranscriptionTranscription regulation

Coding sequence diversity

Chromosomal rearrangement

Molecular function

CyclinRepressor

Cellular component

CytoplasmMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Disease

Proto-oncogene

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