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Estrogen Receptor beta Antibody

CAT: 0013-GTR18082628-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082628-01Size:20 µg
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Description
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
UniProt
Q92731
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the Estrogen Receptor beta antibody.
Clonality
Monoclonal
Clone
ESR2/3207
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA-free format for coating)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Estrogen Receptor beta antibody should be determined by the researcher.
Tested Applications
ELISA
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · Q92731

Estrogen receptor beta

ESR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92731
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ESR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ER-beta
EC number
—
Processing
—
Secondary accessions
A8K8K5, G3V5M5, O60608, O60685, O60702, O60703, O75583, O75584, Q0MWT5, Q0MWT6, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Cellular component

Nucleus

PTM

Phosphoprotein

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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