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Estrogen Receptor alpha Antibody

CAT: 0013-GTR18082623-01Size: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0013-GTR18082623-01Size:0.1 mL
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Description
This monoclonal antibody is specific to estrogen receptor alpha (ER alpha) and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.
UniProt
P03372
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this Estrogen Receptor alpha antibody.
Clonality
Monoclonal
Clone
1D5
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Culture supernatant
Dilution
Immunohistochemistry (FFPE) : 1:100-1:200
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Estrogen Receptor alpha antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
Culture supernatant with 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P03372

Estrogen receptor

ESR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P03372
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ESR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ER
EC number
—
Processing
—
Secondary accessions
Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative promoter usageAlternative splicing

Cellular component

Cell membraneCytoplasmGolgi apparatusMembraneNucleus

Disease

Disease variantOsteoporosis

PTM

GlycoproteinLipoproteinMethylationPalmitatePhosphoproteinUbl conjugation

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

TransmembraneZinc-finger

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