CDK2 Antibody

CAT: 0013-GTR18082594-02Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18082594-02Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

In vertebrates, as in yeast, multiple cyclins have been identified, including a total of eight such regulatory proteins in mammals. In contrast to the situation in yeast, the Cdc2 p34 kinase is not the only catalytic subunit identified in vertebrates that can interact with cyclins. While Cdc2 p34 is essential for the G2 to M transition in vertebrate cells, a second Cdc2-related kinase has also been implicated in cell cycle control. This protein, designated cyclindependent kinase 2 (Cdk2), also binds to cyclins and its kinase activity is temporally regulated during the cell cycle. Several additional Cdc2-related cyclin dependent kinases have been identified. These include Cdk3, Cdk4, Cdk5, PCTAIRE-1, PCTAIRE-2, PCTAIRE-3, Cdk6 Cdk7, Cdk8 and KKIALRE.

UniProt

P24941

Reactivity

Human, Mouse

Immunogen

Recombinant human CDK2 was used as the immunogen for this CDK2 antibody.

Clonality

Monoclonal

Clone

AN4.3

Conjugation

Unconjugated

Field of Research

Epigenetics & Chromatin

Purification

Protein G affinity chromatography

Dilution

Western blot: 1-2ug/ml, Flow cytometry: 1-2ug/10^6 cells in 0.1ml

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the CDK2 antibody should be determined by the researcher.

Tested Applications

FACS, WB

Host or Source

Mouse

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide

Isotype

Mouse IgG2a, kappa

UniProtKB · P24941

Cyclin-dependent kinase 2

CDK2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P24941
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CDK2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.11.22
Processing: —
Secondary accessions: A8K7C6, O75100

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinS-nitrosylation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

Cell cycleCell divisionDNA damageDNA repairMeiosisMitosis

Cellular component

CytoplasmCytoskeletonEndosomeNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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