Annexin A1 Antibody

CAT: 0013-GTR18083135-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18083135-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

UniProt

P04083

Reactivity

Human

Immunogen

Recombinant human full-length protein was used as the immunogen for the Annexin A1 antibody.

Clonality

Monoclonal

Clone

ANXA1/1671

Conjugation

Unconjugated

Field of Research

Epigenetics, Immunology

Purification

Protein G affinity chromatography

Dilution

Flow cytometry: 1-2ug/million cells, Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Western blot: 1-2ug/ml

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the Annexin A1 antibody to be determined by the researcher.

Tested Applications

FACS, IHC-P, WB

Host or Source

Mouse

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide

Isotype

Mouse IgG2b, kappa

UniProtKB · P04083

Annexin A1

ANXA1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P04083
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ANXA1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B5BU38

Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

PTM

AcetylationDisulfide bondIsopeptide bondPhosphoproteinUbl conjugation

Biological process

Adaptive immunityImmunityInflammatory responseInnate immunity

Domain

AnnexinRepeat

Ligand

CalciumCalcium/phospholipid-bindingMetal-binding

Cellular component

Cell membraneCell projectionCiliumCytoplasmCytoplasmic vesicleEndosomeMembraneNucleusSecreted

Molecular function

Phospholipase A2 inhibitor

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