Recombinant PAX8 Antibody

CAT: 0013-GTR18082746-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18082746-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

UniProt

Q06710

Reactivity

Human

Immunogen

A human recombinant fragment (aa 60-261) was used as the immunogen for the recombinant PAX8 antibody.

Clonality

Recombinant

Clone

PAX8/2774R

Conjugation

Unconjugated

Field of Research

Stem Cell & Developmental Biology

Purification

Protein A affinity chromatography

Dilution

Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

The stated application concentrations are suggested starting points. Titration of the recombinant PAX8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Rabbit

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide

Isotype

Rabbit IgG, kappa

UniProtKB · Q06710

Paired box protein Pax-8

PAX8_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q06710
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PAX8
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q09155, Q16337, Q16338, Q16339, Q4ZG35, Q96J49

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Congenital hypothyroidismDisease variant

Molecular function

Developmental proteinDNA-binding

Biological process

DifferentiationTranscriptionTranscription regulation

Cellular component

Nucleus

Domain

Paired box

PTM

Phosphoprotein

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