Products for Research Use Only

Recombinant ODC1 Antibody

CAT: 0013-GTR18082613-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082613-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1) . ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
UniProt
P11926
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the recombinant ODC1 antibody.
Clonality
Recombinant
Clone
ODC1/2878R
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein A affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 0.25-0.5ug/ml for 30 min at RT, Western blot: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant ODC1 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P, WB
Host or Source
Rabbit
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Rabbit IgG, kappa

UniProtKB · P11926

Ornithine decarboxylase

DCOR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11926
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ODC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ODC
EC number
4.1.1.17
Processing
—
Secondary accessions
Q53TU3, Q6LDS9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

DecarboxylaseLyase

Disease

Disease variantHypotrichosis

PTM

PhosphoproteinS-nitrosylation

Biological process

Polyamine biosynthesis

Ligand

Pyridoxal phosphate