Verucopeptin

CAT: 0804-HY-P2657-01Size: 25 µgDry Ice: NoHazardous: No

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CAT#:0804-HY-P2657-01Size:25 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Verucopeptin is a potent HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR) cancers and can be used for cancer research.

CAS Number

138067-14-8

UNSPSC

12352209

Target

Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Proton Pump

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/verucopeptin.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C([C@@](O)(C(O[C@@H]1/C(C)=C/[C@@H](C)C[C@@H](C)C[C@H](C)CC)(CC[C@@H]1OC)O)C)N[C@H](C(N(NCCC2)[C@@]2([H])C(N(CC(N(C3)C)=O)O)=O)=O)[C@@H](OC(CN(C(CNC3=O)=O)C)=O)C(C)C

Molecular Formula

C43H73N7O13

Molecular Weight

896.08

References & Citations

[1]Aya Yoshimura, et al.Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete. Org Lett. 2015 Nov 6;17 (21) :5364-7.|[2]Nobuaki Takahashi, et al. Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1) . Chem Commun (Camb) . 2019 Oct 1;55 (79) :11956-11959.|[3]Yuezhou Wang, et al. Pharmacological Targeting of Vacuolar H +-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Jun 30; S2451-9456 (20) 30234-8.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

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