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Bax Antibody

CAT: 0013-GTR18082327-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082327-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCL2 associated X protein/Bax accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. [UniProt]
UniProt
Q07812
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the Bax antibody.
Clonality
Monoclonal
Clone
ARBX-1
Conjugation
Unconjugated
Field of Research
Apoptotic, Cancer, Epigenetics, Infectious Diseases, Neuroscience, Signaling Pathways
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT (1), Prediluted IHC only format: incubate for 30 min at RT (2)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Bax antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1

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