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CaVα2δ1 rabbit pAb

CAT: 0855-ES20793-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20793-01Size:50 µL
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Background
Calcium voltage-gated channel auxiliary subunit alpha2delta 1 (CACNA2D1) Homo sapiens The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Description
Calcium voltage-gated channel auxiliary subunit alpha2delta 1 (CACNA2D1) Homo sapiens The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014],
UniProt
P54289
Swiss Prot
P54289
Reactivity
Rat
Immunogen
Synthetic Peptide of CaVα2δ1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
100-130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
100-130kD
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type I membrane protein .
Other Product Names
Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]
Gene ID (Human)
781

UniProtKB · P54289

Voltage-dependent calcium channel subunit alpha-2/delta-1

CA2D1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54289
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CACNA2D1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q17R45, Q9UD80, Q9UD81, Q9UD82
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Molecular function

Calcium channelIon channelVoltage-gated channel

Biological process

Calcium transportIon transportTransport

Cellular component

Cell membraneMembrane

Disease

Disease variantEpilepsyIntellectual disability

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

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